It was suggested that the oral intake of L-Theanine could cause anti-stress effects via the inhibition of cortical neuron excitation.

Study results suggest that L-Theanine and caffeine, in combination, are beneficial for improving performance on cognitively demanding tasks.

Caffeine supplementation showed a significant ergogenic effect on muscle endurance and maximum strength in the bench press exercise.

This study suggests that caffeine could be considered as a supplementation strategy for female athletes competing in team sports.

Study findings suggest that L-Theanine has the potential to promote mental health in the general population with stress-related ailments and cognitive impairments.

The intake of a low/moderate dose of caffeine before and/or during exercise can improve self-reported energy, mood, and cognitive functions, such as aattention; it may also improve simple reaction time, choice reaction time, memory, or fatigue, however, this may depend on the research protocols.

The intake of a low/moderate dose of caffeine before and/or during exercise can improve self-reported energy, mood, and cognitive functions, such as attention; it may also improve simple reaction time, choice reaction time, memory, or fatigue. However, this may depend on the research protocols.

Coffee and caffeine consumption are significantly associated with decreased risk of depression.

In the last decades, increased knowledge about collagen's organization, structure, and properties (particularly concerning interactions between cells and collagen-based materials) has inspired scientists and engineers to design innovative collagen-based biomaterials and develop novel tissue-engineering products.

Scientists speculate that various chemical compounds, including hericenones, in the mushroom have multiple effects on the brain's neural networks and improve cognitive functions.

Cordyceps Sinensis has various biological and pharmacological functions, and it has been claimed as a tonic supplement for sexual and reproductive dysfunctions for a long time in oriental society.

Evidence from in vitro and in vivo studies has demonstrated that reishi possesses potential anticancer activity through immunomodulatory, anti-proliferative, pro-apoptotic, anti-metastatic, and anti-angiogenic effects.

One of the potential candidates against the SARS-CoV-2 virus may be Inonotus obliquus (IO), also known as Chaga mushroom.

Data for dream salience suggests that Vitamin B-6 may act by increasing cortical arousal during periods of rapid eve movement (REM) sleep. A hypothesis is presented involving the role of B-6 in the conversion of tryptophan to serotonin.

A review concluded extracts and flavonoids (mainly quercetin, apigenin, and vitexin) from Passiflora could be a valuable source of anti-inflammatory and anti-oxidative medications for the prevention and treatment of many diseases which occur with complex inflammatory processes.

A study showed that sleep efficiency and wake after sleep onset (WASO) significantly improved after taking passionflower extract for two weeks.

Melatonin intervention in subjects with Respiratory diseases, Metabolic disorders, and sleep disorders significantly affects sleep quality.

Melatonin seems to be a glucose-metabolic safe sleep aid in patients with metabolic diseases and healthy adults. It may even have beneficial glucose-metabolic effects.

A study provides sufficient evidence to support clinical trials that could eventually lead to curcumin's acceptance as standard therapy for many forms of arthritis and possibly other inflammatory conditions.

A study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption, and bioavailability of curcumin in both rats and humans with no adverse effects.

A study provides evidence for curcumin's anti-inflammatory effects and supports further investigation to confirm dose, duration, and formulation to optimize anti-inflammatory effects in humans with chronic inflammation.

Eleven studies were made to evaluate the effects of oral turmeric supplementation in the treatment of chronic inflammatory skin diseases. The skin conditions examined include psoriasis, pruritus, oral lichen planus, facial redness, and types of skin cancers. Overall, oral turmeric supplementation has shown therapeutic benefits for skin health.

The desirable preventive or putative therapeutic properties of curcumin have also been considered to be associated with its antioxidant and anti-inflammatory properties.

Six clinical trials with 377 patients were reviewed In Meta-Analysis, comparing the use of curcumin to placebo. In patients with depression, the pooled standardized mean difference from the baseline Hamilton Rating Scale for Depression supports the significant clinical efficacy of curcumin in ameliorating depressive symptoms. Significant anti-anxiety effects were also reported in 3 of the trials.

According to the Meta-analysis that included seven eligible studies (649 patients), turmeric and curcumin may protect patients at risk of cardiovascular disease (CVD) by improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs.

Animal studies suggested that vitamin E treatment prevented cartilage degeneration and improved oxidative status in animal models of osteoarthritis. Vitamin E may retard the progression of osteoarthritis by ameliorating oxidative stress and inflammation of the joint.

Clinical trials have reported a beneficial effect of chondroitin sulfate and glucosamine sulfate on pain and function. The structure-modifying impacts of these compounds have been reported and analyzed in recent meta-analyses.

Meta-analysis indicated that glucosamine is superior to placebo in alleviating Knee Osteoarthritis symptoms.